|
KMID : 0043319880110020114
|
|
Archives of Pharmacal Research
1988 Volume.11 No. 2 p.114 ~ p.121
|
|
|
Studies on Reaction of Fromaldehyde with Naturally Occurring Thiol Compounds and Ascorbic Acid
|
|
Trezl L
Cho YB/Dimaria P/Kim SD/Lotlikar PD/Park WK
|
|
|
Abstract
|
|
|
|
To gain insight into possible cellular protective mechanisms against the insult of formaldehyde, we have investigated this molecule’’s reactivity with both naturally occurring thiol compounds including glutathione and L-ascorbic acid. By UV measurements, formaldehyde was found to rapidly react with glutathione forming an S-hydroxymethyl covalent adduct. The adduct which was confirmed by NMR is transiently stable. Formaldehyde is also significantly reactive with L-ascorbic acid in a reaction which was observed to be dissimilar to its reaction with dimedone. The reaction of formaldehyde with glutathione was reduced by 40% in the presence of an excess amount of L-ascorbic acid, due to the trapping of formaldehyde by L-ascorbic acid. The data suggest that L-ascorbic acid may have a possible in vivo role in the metabolism of formaldehyde, thereby protecting cellular glutathione from possible depletion.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|